With life expectancy increasing, neurodegenerative diseases are taking an ever-increasing toll on society. Several of these diseases are characterized by a selective degeneration of particular classes of neurons. Our laboratory focuses on understanding how the physiology of vulnerable neurons contributes to their degeneration as well as studying adaptive physiological responses to degeneration within neural networks.
Our research focuses on Parkinson’s disease (PD) and particularly on the physiological basis of prodromal symptoms of PD (e..g, that appear years before diagnosis). We study it using genetic and other models of PD. We are also interested in the cellular physiology of neurons and circuits in the Basal Ganglia. Our work combines neurophysiological experiments, advanced imaging techniques and mathematical modeling.
ow hiring postdocs and PhD students for an EU consortium grant on anxiety and depression in Parkinson’s disease